Endocrine Abstracts

A 45-year-old Caucasian man with BMI of 34 presented with a few years’ history of low libido and premature ejaculation. He had azoospermia in the past for infertility investigation 4 years ago with his previous relationship. His LH and FSH were high at 18 U/l(2-13 U/l) and 10 U/l(2-9 U/l) while his 9 amtestosterone level was 19.2 nmol/l(10-38 nmol/l) along with normal prolactin and TSH. The testicular examination is unremarkable. His repeat semen analysis shows azoospermi...

Introduction: There are reports of patients having co-existing primary hyperparathyroidism and familial hypocalciuric hypercalcaemia (FHH). The combination of relative hypocalciuria, hypercalcaemia and slightly elevated serum parathyroid hormone (PTH) could indicate FHH. Medications such as, lithium and bendroflumethiazide can reduce renal excretion of calcium. We report a case highlighting the importance of being aware of drug-induced hypocalciuria during the investigation of...

Introduction: Single-electrolyte derangement is a common biochemical finding. Multiple-electrolytes derangement is less common and require multiple and simultaneous corrective therapies. We present a patient who had multiple admissions with multiple-electrolytes derangement, which after further evaluation required a single therapeutic intervention.Case: A 26-year-old lady had eight admissions over three years with abdominal pain and vomiting. During each...

Introduction: Single-electrolyte derangement is a common biochemical finding. Multiple-electrolytes derangement is less common and require multiple and simultaneous corrective therapies. We present a patient who had multiple admissions with multiple-electrolytes derangement, which after further evaluation required a single therapeutic intervention.Case: A 26-year-old lady had eight admissions over three years with abdominal pain and vomiting. During each...

Introduction: Acromegaly is a rare metabolic condition in adults caused by over secretion of growth hormone from the pituitary gland. The characteristic skeletal and organ overgrowth and dental mal-occlusion issues are so insidious that they go unnoticed by the patient and family. The dentist may be the first healthcare provider to see these patients, thereby proving instrumental in early diagnosis. We report two cases of acromegaly: one case identified by a dentist and anothe...

Background: The prevalence of iodine-based contrast media-induced (ICM-induced) thyroid dysfunction varies (1-15%). Contrast-induced hyperthyroidism is predominantly found in iodine-deficient regions and in patients with underlying nodular goitre or latent Graves’ disease. Beta-blockers are first-line therapy, but anti-thyroid medication are used for severe symptomatic cases.Case Report: A 79-year-old man presented with a 4-day history of bilious vo...

Introduction: Pembrolizumab is an immune checkpoint inhibitor (ICI) used to treat advanced cancers. While improving survival rates, ICIs also cause immune-related adverse events (IRAEs). The endocrine system remains the most vulnerable to IRAEs: thyroid involvement is the commonest while pancreatic involvement is rare, affecting less than 1% of individuals. Risk factors for IRAEs include, personal or family history of autoimmune conditions, presence of another...